Rapidly progressive obstructive jaundice due to Congo red negative amyloidosis.

Hepatic involvement in amyloidosis is common but obstructive jaundice is a very rare complication. Occasional patients with AL amyloidosis develop obstructive jaundice as a consequence of severe intrahepatic cholestasis, but review of the English literature reveals only 23 such cases. We report a further case of obstructive jaundice due to amyloidosis in which the diagnosis was particularly difficult to establish because the amyloid material was Congo red negative.